Current Issue : July-September Volume : 2018 Issue Number : 3 Articles : 6 Articles
Objective of present work was design and development of taste masked orodispersible tablet of raloxifene hydrochloride (HCl). In current research, the orodispersible tablets of antiosteoporetic agent, raloxifene hydrochloride were formulated by direct compression method. Tablets were prepared using Eudragit EPO as taste masking agent, mucilage of Hibiscus rosa-sinensis used as solubility enhancer, sodium starch glycolate used as superdisintegrating agent, micro crystalline cellulose used as direct compression polymer and aspartame as sweetening agent. 32 Full factorial design was used to optimize % drug release and disintegrating time. The concentration of HRSM (X1) and concentration of SSG (X2) were selected as independent variables. The drug release (Y1) and disintegrating time (Y2) were selected as dependent variables. The prepared tablets were evaluated for thickness, hardness, weight variation, friability, wetting time and % drug content. FTIR study was carried out for drug and excipients compatibility study. Taste masking evaluation was evaluated by electronic-tongue. Raloxifene hydrochloride taste masked orodispersible tablets prepared and found to be of good quality gratifying all the requirements for orodispersible tablet. The results indicated that X1 and X2 significantly affected the % drug release (Y1) and disintegrating time (Y2). Regression analysis and numerical optimization were performed to identify the best formulation. The Taste masked orodispersible tablet of antiosteoporetic agent, raloxifene HCl was formulated successfully by direct compression method....
Many drugs have poor water solubility and for oral delivery of such drugs are usually associated with limitation of low bioavailability. Develop a stable micellar formulation for poorly water soluble drugs having an excellent capacity to increase solubilization and bioavailability. The aim of study was to develop micelles formulation for oral delivery of norfloxacin. Developed micelle contains a lipophilic drug norfloxacin, using Pluronic F-68 prepared by Sonication method. They were characterized for FTIR, XRD, SEM, stability and solubility. The peaks of drugs and polymer were found in FTIR analysis shows there were no interaction between drug and polymer. XRD diffractogram of norfloxacin shows characteristic crystalline peaks at 13.250°, 20.780°, 25.090°. The XRD diffractograms of polymeric micelles shows the same characteristic crystalline peaks at 13.250°, 20.780°, 25.090° but with less intensity. SEM studies revealed surface morphology and size reduction of norfloxacin in formulated batches. Solubility of formulation was found to be in the range of 0.246 to 0.710 % release of norfloxacin. Out of 9 formulated batches, formulation TMM 5 released maximum 0.710% and formulation TMM 7 released minimum 0.246% of drug. Absence of turbidity in the solution between 1.2 to 3 as well as microscopy of the filter suggested that there was no aggregation or precipitate of the micelles. This suggests micelles were stable in the acidic pH. It was concluded that the micelles drug delivery of norfloxacin showed a better solubility, stability of micelles. Prepared polymeric micelles system can be used as a prospective delivery carrier for norfloxacin....
Capsaicin is the most abundant of capsaicinoid which is the pungent metabolite in the fruits of Capsicum species. Capsaicinoid is responsible for about 90% of total pungency in the fruit. Capsaicin has been used as a topical analgesic against rheumatoid arthritis pain and inflammation. The aim of the proposed research work was to formulate microemulsion incorporating chilli extract for topical therapy of rheumatoid arthritis. Eucalyptus oil/ wintergrass oil are also known to have additional benefits in the anti-inflammatory therapy. Hence the attempts were made to formulate a simple emulsion containing Capsicum frutescence extract using eucalyptus oil/ wintergrass oil. It was found that simple emulsion shows lack of solubility of the extract. Hence the approach of microemulsion was preferred to formulate microemulsion by using Span 20, Tween 60, Stearic acid was used as surfactant and Ethanol as cosurfactant. A phase diagram was constructed using Eucalyptus oil/ Wintergrass oil as oil phase. Emulgel was evaluated for influence of various temperatures, organoleptic test, pH, globule diameter, viscosity and consistency. The microemulsion formulation was found to be stable in Freeze-thaw study. The penetration of capsaicinoid from each dosage forms was evaluated using Franz diffusion cell. The result showed that chili fructus extract is containing 1.93±0.2% capsaicinoid. The percentage of penetrated capsaicinoid from emulgel dosage form was 98.118%....
Topical delivery is an attractive route for the local and systemic treatment. The delivery of the drugs onto the skin is recognized as an effective means of therapy for local dermatologic diseases. Topical gels are becoming more popular due to ease of application and better precutaneous absorption. Topical gel drug administration is a localized drug delivery system anywhere in the body through ophthalmic, rectal, vaginal and skin as topical routs. Gel formulation provides better application property and stability in comparison to cream and ointment. Topical application of drugs offers potential advantages of delivering the drug directly to site of action and acting for an extended period of time. The purpose of the present work was to develop topical drug delivery system of ketoconazole. The gel formulation was designed by using Ocimum basilicum mucilage, Carbopol 940 and HPMC K100M as gelling agents. The physicochemical parameters of all formulations were determined. In-vitro drug release study of F2 formulation shows the 94.16% drug release and permeation studies done with cadaver skin of F2 formulation shows 89.57% drug release in 6 hrs respectively. The stability study revealed no significant difference between before and after storage....
The aim of present work was to develop a topical bioadhesive gel of lornoxicam by using three level factorial design and evaluate the effects of two independent variables {amount of carbopol (934 = X1) and sodium carboxymethylcellulose (NaCMC) = X2)} on the dependent variable (bioadhesiveness, viscosity and in-vitro drug release). In the present research work, the different concentration of polymers including carbopol 934 and sodium caboxymethyl cellulose (NaCMC) were studied. The topical bioadhesive gel was evaluated for viscosity, bioadhesiveness, in-vitro studies, texture analysis and spreadability. Optimized formulation was further evaluated by in-vitro studies, in-vivo studies and accelerated stability studies. The optimized concentration of cabopol 934 and sodium caboxymethyl cellulose was found to be 1.5%. Batch A7 showed the highest bioadhesion i.e. 85g with highest in-vitro drug release i.e. 74%. It was concluded that formulated topical gel was able to show permeation and reduces the inflammation....
The objective of the present research work was to systemically device a model of nifedipine extended release tablet and optimization of drug release according to the U.S.P. In this study, the nifedipine extended release tablet were formulated using polymer HPMC K4M and HPMC K100M by wet granulation method and HPMC K4M was also added extra granularly. These formulations were evaluated for the parameters like thickness, hardness, weight variation, drug content uniformity, % friability, in-vitro drug release according to the U.S.P and accelerated stability studies. On the basis of preliminary results, the amount of HPMC K4 M (X1) and and the amount of HPMC K100M (X2) were chosen as independent variables in 32 full factorial design, while % CDR at 4 hours and 12 hours were selected as dependent variables. Multiple linear regression analysis, ANOVA and graphical representation of the influence of factor by contour plots were performed using Design Expert 9. Check point batch was prepared to validate the evolved model. Optimized batch was found to be stable in the stability evaluation....
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